Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin

Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated...

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Main Authors:	Chan, King Chi, Chan, Lai Sheung, Ip, Joseph Chok Yan, Lo, Carman, Yip, Timothy Tak Chun, Ngan, Roger Kai Cheong, Wong, Ricky Ngok Shun, Lo, Kwok Wai, Ng, Wai Tong, Lee, Anne Wing Mui, Tsao, George Sai Wah, Kahn, Michael, Lung, Maria Li, Mak, Nai Ki
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Subjects:	Article
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404684/
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