Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer
Polycomb repressive complex 2 (PRC2), which is responsible for the trimethylation of H3K27 (H3K27me3), plays a part in tumorigenesis, development and/or maintenance of adult tissue specificity. The pivotal role of PRC2 in cancer makes it a therapeutic target for epigenetic cancer therapy. However, n...
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| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2015
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| Subjects: | |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536998/ |
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