Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

BACKGROUND: The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) identified in Tugela Ferry, KwaZulu-Natal, South Africa, in 2005 that c...

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Main Authors:	Cohen, Keira A., Abeel, Thomas, Manson McGuire, Abigail, Desjardins, Christopher A., Munsamy, Vanisha, Shea, Terrance P., Walker, Bruce J., Bantubani, Nonkqubela, Almeida, Deepak V., Alvarado, Lucia, Chapman, Sinéad B., Mvelase, Nomonde R., Duffy, Eamon Y., Fitzgerald, Michael G., Govender, Pamla, Gujja, Sharvari, Hamilton, Susanna, Howarth, Clinton, Larimer, Jeffrey D., Maharaj, Kashmeel, Pearson, Matthew D., Priest, Margaret E., Zeng, Qiandong, Padayatchi, Nesri, Grosset, Jacques, Young, Sarah K., Wortman, Jennifer, Mlisana, Koleka P., O'Donnell, Max R., Birren, Bruce W., Bishai, William R., Pym, Alexander S., Earl, Ashlee M.
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Subjects:	Research Article
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587932/
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