Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin-Based Chemoradiotherapy Regimen for Head and Neck Carcinomas

Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15–29 mL/min). However, although clinically important, in none of the randomized trials is grade...

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Main Authors:	Hoek, Jantien, Bloemendal, Karen M., van der Velden, Lilly-Ann A., van Diessen, Judi N.A., van Werkhoven, Erik, Klop, Willem M.C., Tesselaar, Margot E.T.
Format:	Online
Language:	English
Published:	MDPI 2016
Subjects:	Article
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773744/
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