Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells

BACKGROUND: Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 in vitro. METHODS: A549 cells were pre-treated with S2505 (10 μM), S2871 (10 μM) with/without SB203580 (10 μM) for 60 mi...

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Bibliographic Details

Main Authors:	Xiang, Shulin, Zeng, Yi, Xiong, Bin, Qin, Yueqiu, Huang, Xia, Jiang, Yujie, Luo, Weigui, Sooranna, Suren R., Pinhu, Liao
Format:	Online
Language:	English
Published:	BioMed Central 2016
Subjects:	Research
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902962/
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